NSAIDs

Web publication date: 28 June 2010 (based on September 2009 search)

Peter C Gøtzsche

Efficacy (7)
Key points
GRADE table
Background
References
Credits
Citations (19)
Guidelines (4)

Overview

Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-inflammatory, analgesic, and antipyretic effects, and they inhibit platelet aggregation. This review deals specifically with the use of NSAIDs for the treatment of the symptoms of musculoskeletal conditions. NSAIDs have no documented effect on the course of musculoskeletal diseases. NSAIDs inhibit the enzyme cyclo-oxygenase (COX), which has two known isoforms: COX-1 and COX-2. NSAIDs are often categorised according to their ability to inhibit the individual isoforms, with newer NSAIDs often predominantly inhibiting the COX-2 isoform and older NSAIDs often being less specific inhibitors.

Latest citations

Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. (22 April 2014)

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials. (11 March 2014)