NSAIDs

Overview

Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-inflammatory, analgesic, and antipyretic effects, and they inhibit platelet aggregation. This review deals specifically with the use of NSAIDs for the treatment of the symptoms of musculoskeletal conditions. NSAIDs have no documented effect on the course of musculoskeletal diseases. NSAIDs inhibit the enzyme cyclo-oxygenase (COX), which has two known isoforms: COX-1 and COX-2. NSAIDs are often categorised according to their ability to inhibit the individual isoforms, with newer NSAIDs often predominantly inhibiting the COX-2 isoform and older NSAIDs often being less specific inhibitors.

Latest citations

Bleeding Risk of Patients With Acute Venous Thromboembolism Taking Nonsteroidal Anti-Inflammatory Drugs or Aspirin. (06 June 2014)

Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain. (06 June 2014)